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December 2014 CoverDecember 2014 | Volume 122 | Issue 12

On the Cover

Detroit has a long history of heavy industrialization; without visiting the city, it is easy to imagine a ruined metropolis. But even the most cursory inspection offers evidence of resilience in the face of repeated environmental injuries. In the words of Detroit’s motto, “We hope for better things; it will arise from the ashes.”

Detroit Iron and Steel Company, circa 1903: © Niday Picture Library/Alamy

December 2014 | Volume 122 | Issue 12


Arising from the Ashes? Environmental Health in Detroit

Tim Lougheed | A324

Advanced Thinking: Potable Reuse Strategies Gain Traction

Richard Dahl | A332

Ritual Risk: Incense Use and Cardiovascular Mortality

Nancy Averett | A336

Also see Pan et al., p. 1279

Assessing the Impact of Aerial Spraying: Mancozeb Exposures among Pregnant Women Living near Banana Plantations

Carol Potera | A337

Also see van Wendel de Joode et al., p. 1321

PFOA and High Cholesterol: Basis for the Finding of a Probable Link

Kellyn S. Betts | A338

Also see Winquist and Steenland, p. 1299

EDCs and Estrogen Receptor Activity: A Pathway to Safer Chemical Design?

Julia R. Barrett | A339

Also see Delfosse et al., p. 1306


Molecular Signaling Network Motifs Provide a Mechanistic Basis for Cellular Threshold Responses

Qiang Zhang, Sudin Bhattacharya, Rory B. Conolly, Harvey J. Clewell III, Norbert E. Kaminski, and Melvin E. Andersen | 1261

Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress

Daniel T. Shaughnessy, Kimberly McAllister, Leroy Worth, Astrid C. Haugen, Joel N. Meyer, Frederick E. Domann, Bennett Van Houten, Raul Mostoslavsky, Scott J. Bultman, Andrea A. Baccarelli, Thomas J. Begley, Robert W. Sobol, Matthew D. Hirschey, Trey Ideker, Janine H. Santos, William C. Copeland, Raymond R. Tice, David M. Balshaw, and Frederick L. Tyson | 1271


Incense Use and Cardiovascular Mortality among Chinese in Singapore: The Singapore Chinese Health Study

An Pan, Maggie L. Clark, Li-Wei Ang, Mimi C. Yu, Jian-Min Yuan, and Woon-Puay Koh | 1279

Also see Science Selections, p. A336

Comparative Assessment of the Effects of Climate Change on Heat- and Cold-Related Mortality in the United Kingdom and Australia

Sotiris Vardoulakis, Keith Dear, Shakoor Hajat, Clare Heaviside, Bernd Eggen, and Anthony J. McMichael | 1285

Variability in Temperature-Related Mortality Projections under Climate Change

Tarik Benmarhnia, Marie-France Sottile, Céline Plante, Allan Brand, Barbara Casati, Michel Fournier, and Audrey Smargiassi | 1293

Modeled PFOA Exposure and Coronary Artery Disease, Hypertension, and High Cholesterol in Community and Worker Cohorts

Andrea Winquist and Kyle Steenland | 1299

Also see Science Selections, p. A338

Structural and Functional Profiling of Environmental Ligands for Estrogen Receptors

Vanessa Delfosse, Marina Grimaldi, Vincent Cavaillès, Patrick Balaguer, and William Bourguet | 1306

Also see Science Selections, p. A339

Household Cooking with Solid Fuels Contributes to Ambient PM2.5 Air Pollution and the Burden of Disease

Zoë A. Chafe, Michael Brauer, Zbigniew Klimont, Rita Van Dingenen, Sumi Mehta, Shilpa Rao, Keywan Riahi, Frank Dentener, and Kirk R. Smith | 1314

Children’s Health

Aerial Application of Mancozeb and Urinary Ethylene Thiourea (ETU) Concentrations among Pregnant Women in Costa Rica: The Infants’ Environmental Health Study (ISA)

Berna van Wendel de Joode, Ana María Mora, Leonel Córdoba, Juan Camilo Cano, Rosario Quesada, Moosa Faniband, Catharina Wesseling, Clemens Ruepert, Mattias Öberg, Brenda Eskenazi, Donna Mergler, and Christian H. Lindh | 1321

Also see Science Selections, p. A337

Risks and Benefits of Green Spaces for Children: A Cross-Sectional Study of Associations with Sedentary Behavior, Obesity, Asthma, and Allergy

Payam Dadvand, Cristina M. Villanueva, Laia Font-Ribera, David Martinez, Xavier Basagaña, Jordina Belmonte, Martine Vrijheid, Regina Gražulevičienė, Manolis Kogevinas, and Mark J. Nieuwenhuijsen | 1329

Pyrethroid Pesticide Exposure and Parental Report of Learning Disability and Attention Deficit/Hyperactivity Disorder in U.S. Children: NHANES 1999–2002

Lesliam Quirós-Alcalá, Suril Mehta, and Brenda Eskenazi | 1336

Neurobehavioral Function in School-Age Children Exposed to Manganese in Drinking Water

Youssef Oulhote, Donna Mergler, Benoit Barbeau, David C. Bellinger, Thérèse Bouffard, Marie-Ève Brodeur, Dave Saint-Amour, Melissa Legrand, Sébastien Sauvé, and Maryse F. Bouchard | 1343

Green and Blue Spaces and Behavioral Development in Barcelona Schoolchildren: The BREATHE Project

Elmira Amoly, Payam Dadvand, Joan Forns, Mónica López-Vicente, Xavier Basagaña, Jordi Julvez, Mar Alvarez-Pedrerol, Mark J. Nieuwenhuijsen, and Jordi Sunyer | 1351

Characteristics of Walkable Built Environments and BMI z-Scores in Children: Evidence from a Large Electronic Health Record Database

Dustin T. Duncan, Mona Sharifi, Steven J. Melly, Richard Marshall, Thomas D. Sequist, Sheryl L. Rifas-Shiman, and Elsie M. Taveras | 1359


Erratum: “Comparative Assessment of the Effects of Climate Change on Heat- and Cold-Related Mortality in the United Kingdom and Australia”


Erratum: “Aerial Application of Mancozeb and Urinary Ethylene Thiourea (ETU) Concentrations among Pregnant Women in Costa Rica: The Infants’ Environmental Health Study (ISA)”


Erratum: “Performance of Multi-City Land Use Regression Models for Nitrogen Dioxide and Fine Particles”


Erratum: “Nutrient Pollution: A Persistent Threat to Waterways”


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